Exploring the Potential of 3D Visualization Techniques for Usage in Collaborative Design

Best practice for collaborative design demands good interaction between its collaborators. The capacity to share common knowledge about design models at hand is a basic requirement. With current advancing technologies gathering collective knowledge is more straightforward, as the dialog between experts can be supported better. The potential for 3D visualization techniques to become the right support tool for collaborative design is explored. Special attention is put on the possible usage for remote collaboration. The opportunities for current state-of-the-art visualization techniques from stereoscopic vision to holographic displays are researched. A classification of the various systems is explored with respect to their tangible usage for augmented reality. Appropriate interaction methods can be selected based on the usage scenario

High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola.

In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ). After 28 days of follow-up, there were 2/61 (3.2%) recurrent parasitemias in the Coartem group and 4/64 (6.2%) in the ASAQ group (P = 0.72), all classified as re-infections after PCR genotyping (cure rate = 100% [95%CI: 94-100] in both groups). Only one patient (ASAQ group) had gametocytes on day 28 versus five (Coartem) and three (ASAQ) at baseline. Compared with baseline, anemia was significantly improved after 28 days of follow-up in both groups (Coartem: from 54.1% to 13.4%; ASAQ: from 53.1% to 15.9%). Our findings are in favor of a high efficacy of both combinations in Caala. Now that Coartem has been chosen as the new first-line anti-malarial, the challenge is to insure that this drug is available and adequately used

Far from equilibrium steady states of 1D-Schrödinger-Poisson systems with quantum wells I

We describe the asymptotic of the steady states of the out-of equilibrium Schrödinger-Poisson system, in the regime of quantum wells in a semiclassical island. After establishing uniform estimates on the nonlinearity, we show that the nonlinear steady states lie asymptotically in a finite-dimensional subspace of functions and that the involved spectral quantities are reduced to a finite number of so-called asymptotic resonant energies. The asymptotic finite dimensional nonlinear system is written in a general setting with only a partial information on its coefficients. After this first part, a complete derivation of the asymptotic nonlinear system will be done for some specific cases in a forthcoming article. UNE VERSION MODIFIEE DE CE TEXTE EST PARUE DANS LES ANNALES DE L'INSTITUT H. POINCARE, ANALYSE NON LINEAIRE

STR-924: EFFECT OF LOW TEMPERATURE ON THE SHEAR-FATIGUE PERFORMANCE OF REINFORCED CONCRETE BEAMS

This paper investigates the fatigue behaviour of a reinforced concrete beam (without shear reinforcement) at low temperature (-20°C) compared to a similar beam tested near room temperature (+16°C). Two large-scale steel reinforced beams (200 mm x 400 mm x 4200 mm) were fabricated and tested. The beams had temperature differentials over their depth to simulate solar radiation and in-service temperature of the bridges. The beams were cyclically loaded to failure with a stress range representing the ratio of live to dead loads found in most bridges. This study showed that low temperature increased the fatigue life of the reinforced concrete beam by 51%, and changed the mode of failure of the beam from shear fatigue failure at room temperature to flexural fatigue failure at low temperature. It was observed that the low and room temperature beams maintained 65% and 31% of their original flexural rigidity indicating that low temperature mitigated the stiffness degradation of the reinforced concrete caused by fatigue loading. The strains in the tensile reinforcement of the low temperature beam were much lower than the room temperature beam which could be due to the higher strength of concrete and reduction in concrete softening at low temperature which resulted in lower stresses in the tensile reinforcement. The findings of this study show that the contribution of concrete under either static or cyclic load becomes much higher at low temperature

Examining the Gap: Compensation Disparities between Male and Female Physician Assistants.

BACKGROUND: Compensation disparities between men and women have been problematic for decades, and there is considerable evidence that the gap cannot be entirely explained by nongender factors. The current study examined the compensation gap in the physician assistant (PA) profession. METHODS: Compensation data from 2014 was collected by the American Academy of PAs in 2015. Practice variables, including experience, specialty, and hours worked, were controlled for in an ordinary least-squares sequential regression model to examine whether there remained a disparity in total compensation. In addition, the absolute disparity in compensation was compared with historical data collected by American Academy of PAs over the previous 1.5 decades. RESULTS: Without controlling for practice variables, a total compensation disparity of $16,052 existed between men and women in the PA profession. Even after PA practice variables were controlled for, a total compensation disparity of$9,695 remained between men and women (95% confidence interval, $8,438-$10,952). A 17-year trend indicates the absolute disparity between men and women has not lessened, although the disparity as a percent of male compensation has decreased in recent years. CONCLUSIONS: There remain challenges to ensuring pay equality in the PA profession. Even when compensation-relevant factors such as experience, hours worked, specialty, postgraduate training, region, and call are controlled for, there is still a substantial gender disparity in PA compensation. Remedies that may address this pay inequality include raising awareness of compensation disparities, teaching effective negotiation skills, assisting employers as they develop equitable compensation plans, having less reliance on past salary in position negotiation, and professional associations advocating for policies that support equal wages and opportunities, regardless of personal characteristics

Water column gradients beneath the summer ice of a High Arctic freshwater lake as indicators of sensitivity to climate change

Ice cover persists throughout summer over many lakes at extreme polar latitudes but is likely to become increasingly rare with ongoing climate change. Here we addressed the question of how summer ice-cover affects the underlying water column of Ward Hunt Lake, a freshwater lake in the Canadian High Arctic, with attention to its vertical gradients in limnological properties that would be disrupted by ice loss. Profiling in the deepest part of the lake under thick mid-summer ice revealed a high degree of vertical structure, with gradients in temperature, conductivity and dissolved gases. Dissolved oxygen, nitrous oxide, carbon dioxide and methane rose with depth to concentrations well above air-equilibrium, with oxygen values at >150% saturation in a mid water column layer of potential convective mixing. Fatty acid signatures of the seston also varied with depth. Benthic microbial mats were the dominant phototrophs, growing under a dim green light regime controlled by the ice cover, water itself and weakly colored dissolved organic matter that was mostly autochthonous in origin. In this and other polar lakes, future loss of mid-summer ice will completely change many water column properties and benthic light conditions, resulting in a markedly different ecosystem regime

Graphlet eigencentralities capture novel central roles of genes in pathways

Motivation Graphlet adjacency extends regular node adjacency in a network by considering a pair of nodes being adjacent if they participate in a given graphlet (small, connected, induced subgraph). Graphlet adjacencies captured by different graphlets were shown to contain complementary biological functions and cancer mechanisms. To further investigate the relationships between the topological features of genes participating in molecular networks, as captured by graphlet adjacencies, and their biological functions, we build more descriptive pathway-based approaches. Contribution We introduce a new graphlet-based definition of eigencentrality of genes in a pathway, graphlet eigencentrality, to identify pathways and cancer mechanisms described by a given graphlet adjacency. We compute the centrality of genes in a pathway either from the local perspective of the pathway or from the global perspective of the entire network. Results We show that in molecular networks of human and yeast, different local graphlet adjacencies describe different pathways (i.e., all the genes that are functionally important in a pathway are also considered topologically important by their local graphlet eigencentrality). Pathways described by the same graphlet adjacency are functionally similar, suggesting that each graphlet adjacency captures different pathway topology and function relationships. Additionally, we show that different graphlet eigencentralities describe different cancer driver genes that play central roles in pathways, or in the crosstalk between them (i.e. we can predict cancer driver genes participating in a pathway by their local or global graphlet eigencentrality). This result suggests that by considering different graphlet eigencentralities, we can capture different functional roles of genes in and between pathwaysThis study received support from the following sources: The European Research Council (ERC) Consolidator Grant 770827 (awarded to NP); The Spanish State Research Agency AEI 10.13039/501100011033 grant number PID2019-105500GB-I00 (awarded to NP); and University College London Computer Science (awarded to SW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ReviewedPostprint (published version

Identifying cellular cancer mechanisms through pathway-driven data integration

Abstract Motivation Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways as those most internally perturbed by gene expression changes. However, driver genes characteristically perform hub roles between pathways. Therefore, we hypothesize that cancer pathways should be identified by changes in their pathway–pathway relationships. Results To learn an embedding space that captures the relationships between pathways in a healthy cell, we propose pathway-driven non-negative matrix tri-factorization. In this space, we determine condition-specific (i.e. diseased and healthy) embeddings of pathways and genes. Based on these embeddings, we define our ‘NMTF centrality’ to measure a pathway’s or gene’s functional importance, and our ‘moving distance’, to measure the change in its functional relationships. We combine both measures to predict 15 genes and pathways involved in four major cancers, predicting 60 gene–cancer associations in total, covering 28 unique genes. To further exploit driver genes’ tendency to perform hub roles, we model our network data using graphlet adjacency, which considers nodes adjacent if their interaction patterns form specific shapes (e.g. paths or triangles). We find that the predicted genes rewire pathway–pathway interactions in the immune system and provide literary evidence that many are druggable (15/28) and implicated in the associated cancers (47/60). We predict six druggable cancer-specific drug targets.This work was supported by the European Research Council (ERC) Consolidator Grant 770827 and the Spanish State Research Agency AEI 10.13039/501100011033 [grant number PID2019-105500GB-I00].Peer ReviewedPostprint (published version